Per-Olof Berggren

Dr. Per-Olof Berggren is professor of Experimental Endocrinology and director of the Rolf Luft Research Center for Diabetes and Endocrinology at the Karolinska Institutet in Stockholm, Sweden. He is the Mary Lou Held Visiting Professor at the Diabetes Research Institute (DRI), Miller School of Medicine, of the University of Miami in the United States. He also holds several other academic positions around the world, including in South Korea, Singapore, China, and Northern Ireland. He is member of the European Molecular Biology Organization (EMBO), the Korean Academy of Science and Technology, the American Academy of Arts and Sciences, the National Academy of Medicine (U.S.), the Royal Swedish Academy of Sciences Class VII, and served on the Nobel Assembly at Karolinska Institutet (1999-2022).

He has done pioneering work on the fundamental mechanisms regulating the stimulus-response coupling in the endocrine pancreas with seminal contributions in the areas of insulin-secreting pancreatic beta cell Ca2+ handling, phosphorylated inositol compounds, and insulin receptor-operated signaling. He established the anterior chamber of the eye as a transplantation site and the cornea as a natural body window for optical functional imaging at the interface between translational medicine and biotechnology, which represented a breakthrough and a state-of-the-art regenerative medicine approach for treating diabetes.

His publications have been featured in renowned journals such as Nature, Nature Medicine, Nature Protocols, Nature Communications, Physiological Reviews, Science, Cell, Cell Metabolism, and Proceedings of the National Academy of Sciences.

Dr. Berggren joined Tecnológico de Monterrey as Distinguished Visiting Professor in Diabetes and Metabolic Diseases for the Institute for Obesity Research and the School of Medicine and Health Sciences.

• Ph.D., Medical Cell Biology, Uppsala University
• Medical School, Uppsala University
• Medical School, Umeå University

• In vivo Ca2+ dynamics in single pancreatic β-cells. JACOB S, KÖHLER M, TRÖSTER P, VISA M, GARCÍA-PRIETO CF, ALANENTALO T, MOEDE T, LEIBIGER B, LEIBIGER IB, BERGGREN PO. FASEB J 2020 Jan;34(1):945-959.
• IgGs from patients with amyotrophic lateral sclerosis and diabetes target CAvα2δ subunits impairing islet cell function and survival. SHI Y, PARK KS, KIM SH, YU J, ZHAO K, YU L, OH KW, LEE K, KIM J, CHAGGAR K, LI Y, DOLPHIN AC, CATTERALL WA, RYU SH, YANG SN, BERGGREN PO. Proc Natl Acad Sci USA November, 2019.
• Structural basis for delta cell paracrine regulation in pancreatic islets. R ARROJO-DRIGO, S JACOB, C GARCIA-PRIETO, X ZHENG, M FUKUDA, H TRAN THI NHU, O STELMASHENKO, FL MARTINS PECANHA, R RODRIGUES-DIAZ, E BUSHONG, T DEERINCK, S PHAN, Y ALI, I LEIBIGER, M CHUA, T BOUDIER, SH SONG, M GRAF, G AUGUSTINE, M ELLISMAN, PO BERGGREN. Nature Communications 16:10(1):3700, 2019.
• Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate. MH ABDULREDA, DM BERMAN, A SHISHIDO, C MARTIN, M HOSSAMELDIN, A TSHIGGFRIE, LF HERNANDEZ, C RICORDI, J-M PAREL, E JANKOWSKA-GAN, WJ BURLINGHAM, EA ARRIETA-QUINTERO, VL PEREZ, NS KENYON & P-O BERGGREN. Diabetologia 62;(5)811-821,2019. Doi: org/10.1007/s00125-019-4814-4, 2019.
• Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell. MENEGAZ D, WALKER HAGAN D, ALMAÇA J, CIANCIARUSO C, RODRIGUEZ-DIAZ R, MOLINA J, DOLAN RM, BECKER MW, SCHWALIE PC, NANO R, LEBRETON F, KANG C, SAH R, GAISANO HY, BERGGREN PO, BAEKKESKOV S, CAICEDO A, PHELPS EA. Nature Metabolism November 2019, Vol 1, 1110-1126.

More